In the last three years we have been involved in a number of works related to trained immunity (Mata-Martínez, P., et al., Front. Immunol., 2022). We uncovered that the trained process can be boosted by targeting the SHIP-1 phosphatase (Saz-Leal, et al., Cell Reports, 2018). Furthermore, we observed that preparations of heat-killed bacteria can induce TI, conferring protection against different infections such as Candida albicans (Brandi P, et al, Cell Reports, 2022) and SARS-CoV-2 (Del Fresno, et al., Front. Immunol., 2021 ). We are trying to expand the application of this heterologous protection conferred by bacterial preparations to cancer immunotherapy.
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